1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Name:1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide
CAS No.:1566543-28-9
Molecular Formula:C₂₅H₂₈F₃N₇O
Molecular Weight:499.539
Hs Code.:

Synonyms:1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

There total 6 articles about 1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1566544-25-9
1-(3-ethynylphenyl)cyclopropanecarboxamide

: 1566543-66-5
tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1566543-28-9
1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: 1-(3-ethynylphenyl)cyclopropanecarboxamide; tert-butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate; With copper(l) iodide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 0.166667h;

With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.666667h; Further stages; Microwave irradiation;

Reference yield:

: 597563-13-8
1-(3-bromophenyl)cyclopropanecarboxamide

: 1566543-28-9
1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h

1.2: 16 h / 80 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h

3.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 0.67 h / 120 °C / Microwave irradiation

With copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1566544-24-8
1-(3-((triisopropylsilyl)ethynyl)phenyl)cyclopropanecarboxamide

: 1566543-28-9
1-(3-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h

2.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h

2.2: 0.67 h / 120 °C / Microwave irradiation

With copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;