C₃₉H₃₇IO₃

Base Information

• Chemical Name: C₃₉H₃₇IO₃
• CAS No.: 1382734-69-1
• Molecular Formula: C₃₉H₃₇IO₃
• Molecular Weight: 680.625
• Mol file: 1382734-69-1.mol

Synonyms:C₃₉H₃₇IO₃

Chemical Property of C₃₉H₃₇IO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₃₉H₃₇IO₃

There total 6 articles about C₃₉H₃₇IO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

boronic acid pinacol ester (1382734-63-5) + C16H16BrI → C39H37IO3 (1382734-69-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In 1,4-dioxane; water; at 80 ℃; for 14h; Reflux; Inert atmosphere;

Reference yield:

methyl 4-iodosalicylate (18179-39-0) → C39H37IO3 (1382734-69-1)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

3: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Reflux

4: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 14 h / 80 °C

5: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; cesium fluoride; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 3: |Suzuki-Miyaura Coupling / 5: |Suzuki-Miyaura Coupling;

DOI:10.1002/chem.201201985

Reference yield:

C23H21BrO3 (1382734-57-7) → C39H37IO3 (1382734-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 14 h / 80 °C

2: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; cesium fluoride; In 1,4-dioxane; water; dimethyl sulfoxide; 2: |Suzuki-Miyaura Coupling;

DOI:10.1002/chem.201201985

upstream raw materials:

methyl 4-iodosalicylate

C₂₃H₂₁BrO₃

benzyl bromide

methyl 2-(benzyloxy)-4-iodobenzoate

Downstream raw materials:

boronic acid pinacol ester