(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

Base Information

Chemical Name:(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt
CAS No.:1432492-47-1
Molecular Formula:C₁₅H₁₃Cl₂NO₂*ClH
Molecular Weight:346.641
Hs Code.:

Synonyms:(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

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Chemical Property of (R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

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Technology Process of (R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

There total 15 articles about (R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

: 1432048-91-3
(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl] (pyridin-2-yl)methanol

: 1432492-47-1
(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield: 85.7%

: 1432492-78-8
[2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanone

: 1432492-47-1
(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

: 1432492-48-2
(R)-((R)-2-(3,4-dichlorophenyl)oxetan-2-yl)(pyridin-2-yl)methanol hydrochloride

Guidance literature:: [2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanone; With formic acid; [N-[(1S,2S)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; triethylamine; at 35 ℃; for 16h;

With hydrogenchloride; In methanol;
DOI:10.1021/acs.jmedchem.6b00287

Reference yield:

: 1432492-74-4
ethyl 2-(3,4-dichlorophenyl)-2-hydroxy-4-oxobutanoate

: 1432492-47-1
(R)-[(2S)-2-(3,4-dichlorophenyl)oxetan-2-yl](pyridin-2-yl)methanol hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetramethylammonium triacetoxyborohydride; acetic acid / acetonitrile / 40 h / 40 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

3.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 2 h / 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

4.2: 2.5 h / -78 - 20 °C

5.1: triethylamine; Noyori's catalyst / 35 °C

6.1: hydrogenchloride / methanol

With hydrogenchloride; Noyori's catalyst; n-butyllithium; 18-crown-6 ether; potassium tert-butylate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetonitrile;