(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

Base Information

Chemical Name:(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol
CAS No.:139055-95-1
Molecular Formula:C₃₀H₄₆O₃Si₂
Molecular Weight:510.864
Hs Code.:

Synonyms:(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

Suppliers and Price of (2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

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Chemical Property of (2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

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Technology Process of (2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

There total 4 articles about (2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 139055-94-0
(4R)-4-<(1R,3R)-3-Hydroxy-1-methylbutoxy>-6-trimethylsilylhex-5-yn-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 139055-95-1
(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 15h; Ambient temperature;
DOI:10.1039/c39890001025

Reference yield:

: 126764-90-7
Methyl 4-<(4R,6R)-4,6-dimethyl-1,3-dioxan-2-yl>propanoate

: 139055-95-1
(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / TiCl₄, molecular sieves 4A / CH₂Cl₂ / 0.33 h / -78 °C

2: 96 percent / LiAlH₄ / diethyl ether / 6 h / -72 deg C to room temperature

3: 80 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; 4 A molecular sieve; titanium tetrachloride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39890001025

Reference yield:

: 126764-91-8
Methyl (4R)-4-<(4R,3R)-3-Hydroxy-1-methylbutoxy>-6-trimethylsilylhex-5-ynoate

: 139055-95-1
(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / LiAlH₄ / diethyl ether / 6 h / -72 deg C to room temperature

2: 80 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1039/c39890001025