Technology Process of 5-(4-bromophenyl)-5-oxopentanal
There total 1 articles about 5-(4-bromophenyl)-5-oxopentanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-4-(cyclopent-1-en-1-yl)benzene;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 1h;
With
triphenylphosphine;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1002/anie.201106046
- Guidance literature:
-
5-(4-bromophenyl)-5-oxopentanal;
With
trimethylsilyl trifluoromethanesulfonate; triphenylphosphine;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
With
borane-THF; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; dichloromethane;
at -40 ℃;
for 6h;
Inert atmosphere;
With
water; sodium hydrogencarbonate;
In
tetrahydrofuran; methanol; dichloromethane;
at 20 - 40 ℃;
for 2h;
enantioselective reaction;
DOI:10.1002/anie.201106046
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trimethylsilyl trifluoromethanesulfonate; triphenylphosphine / dichloromethane / 1 h / 20 °C / Inert atmosphere
1.2: 6 h / -40 °C / Inert atmosphere
1.3: 2 h / 20 - 40 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
2.2: 4 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; trimethylsilyl trifluoromethanesulfonate; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/anie.201106046
