(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

Base Information

Chemical Name:(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid
CAS No.:91994-30-8
Molecular Formula:C₃₅H₄₇NO₆Si
Molecular Weight:605.847
Hs Code.:

(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

Synonyms:(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

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Chemical Property of (R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

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Technology Process of (R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

There total 6 articles about (R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91994-26-2
(4R,5S)-4-((S)-1-Benzyloxy-ethyl)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-2-enone

: 91994-30-8
(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂NOH*HCl, NaOAc; 2.) TsCl / 2.) dimethylaminopropylamine / 1.) EtOH, 42 h; 2.) pyridine, r.t. -> 65 deg C

3: 381 mg / potassium permanganate, sodium periodate, sodium bicarbonate / 2-methyl-propan-2-ol; H₂O / 1.5 h / Ambient temperature

4: 240 mg / 2 M sodium methoxide / methanol / 1.5 h / 0 °C

With potassium permanganate; sodium periodate; hydroxylamine hydrochloride; sodium methylate; sodium acetate; sodium hydrogencarbonate; p-toluenesulfonyl chloride; 1-amino-3-(dimethylamino)propane; In methanol; water; tert-butyl alcohol;
DOI:10.1021/ja00333a053

Reference yield:

: 91994-32-0
(2S,3R)-2-((S)-1-Benzyloxy-ethyl)-3-(tert-butoxycarbonyl-oxalyl-amino)-5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid

: 91994-30-8
(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

Guidance literature:: With sodium methylate; In methanol; at 0 ℃; for 1.5h;
DOI:10.1021/ja00333a053

Reference yield:

: 91994-27-3
<5S-<5α(S^*),6β>>-6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-5-<1-(phenylmethoxy)ethyl>-2-piperidinone

: 91994-30-8
(R)-2,3,4-trideoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-5-O-<(1,1-dimethylethyl)diphenylsilyl>-2-<1-(phenylmethoxy)ethyl>-D-erythropentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

2: 381 mg / potassium permanganate, sodium periodate, sodium bicarbonate / 2-methyl-propan-2-ol; H₂O / 1.5 h / Ambient temperature

3: 240 mg / 2 M sodium methoxide / methanol / 1.5 h / 0 °C

With potassium permanganate; sodium periodate; sodium methylate; sodium hydrogencarbonate; In methanol; water; tert-butyl alcohol;
DOI:10.1021/ja00333a053