1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

Base Information

Chemical Name:1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea
CAS No.:1349743-44-7
Molecular Formula:C₂₁H₁₉FN₆O
Molecular Weight:390.42
Hs Code.:

Synonyms:1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

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Chemical Property of 1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

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Technology Process of 1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

There total 10 articles about 1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1-(5-cyanopyrazin-2-yl)-3-(3-(2-(4-fluorobenzylamino)ethyl)phenyl)urea trifluoroacetate

: 1349743-44-7
1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

Guidance literature:: With ammonia; In tetrahydrofuran; dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1349743-44-7
1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / -20 °C

1.2: 1.5 h / -30 °C

2.1: hydrogenchloride / water; tetrahydrofuran / 2 h / 100 °C

3.1: acetic acid / methanol / 15 - 20 °C

3.2: 0 - 20 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: zinc; ammonium chloride / methanol / 1 h / 45 °C

6.1: N,N-dimethyl-formamide / 2 h / 80 °C

7.1: dichloromethane / 4 h / 10 °C

8.1: ammonia / dichloromethane; tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; potassium tert-butylate; ammonia; ammonium chloride; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 113305-94-5
2-amino-5-cyanopyrazine

: 1349743-44-7
1-(5-cyano-pyrazin-2-yl)-3-{3-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane; tetrahydrofuran / 0.25 h

1.2: 2 h / 50 °C

2.1: N,N-dimethyl-formamide / 2 h / 80 °C

3.1: dichloromethane / 4 h / 10 °C

4.1: ammonia / dichloromethane; tetrahydrofuran / 1 h / 0 °C

With pyridine; ammonia; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;