5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

Base Information

Chemical Name:5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine
CAS No.:1349770-43-9
Molecular Formula:C₂₄H₂₅N₅O₃S
Molecular Weight:463.56
Hs Code.:

Synonyms:5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

Suppliers and Price of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

There total 13 articles about 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1349770-85-9
tert-butyl N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]-2-pyridyl]carbamate

: 1349770-43-9
5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

Guidance literature:: tert-butyl N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]-2-pyridyl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 905966-34-9
5-bromo-3-(2-(trimethylsilyl)ethynyl)pyridine-2-amine

: 1349770-43-9
5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1: dmap / dichloromethane / 3 h / 20 °C

2: water; sodium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: triethylamine / tetrahydrofuran / 18 h / 20 - 65 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

6: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / ethyl acetate / 2 h / 85 °C

7: dichloromethane; ethanol / 2 h / 20 °C / Sealed tube

8: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 13472-79-2
5-iodo-pyridin-2-ol

: 1349770-43-9
5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; copper(l) iodide / isopropyl alcohol; ethylene glycol / 2 h / 120 °C / Microwave irradiation

2: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 1.17 h / 20 - 954 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

5: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / ethyl acetate / 2 h / 85 °C

6: dichloromethane; ethanol / 2 h / 20 °C / Sealed tube

7: trifluoroacetic acid / dichloromethane / 20 °C

With N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; phosphorus(V) oxybromide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;