(1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

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Chemical Name:(1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide
CAS No.:1107649-49-9
Molecular Formula:C₃₅H₅₁N₃O₃
Molecular Weight:561.808
Hs Code.:

Synonyms:(1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

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Chemical Property of (1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

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Technology Process of (1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

There total 7 articles about (1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3S)-3-amino-1-((3-isopropylbenzyl)amino)-4-phenylbutan-2-ol

: 1107649-51-3
C₁₅H₂₅NO₃

: 1107649-49-9
(1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 7h;

Reference yield:

: 1107649-01-3
(1R,3S)-3-[1-methyl-1-(6-oxo-3,6-dihydro-2H-pyridin-1-yl)-ethyl]-cyclohexane-carboxylic acid methyl ester

: 1107649-49-9
(1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; 1% Pd on activated carbon / methanol

2: lithium hydroxide; water / methanol

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With 1% Pd on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.01.001

Reference yield:

: 1107648-81-6
C₁₁H₂₁NO₂

: 1107649-49-9
(1R,3S)-3-[1-methyl-1-(2-oxo-piperidin-1-yl)-ethyl]-cyclohexanecarboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-3-(3-isopropyl-benzylamino)-propyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / acetonitrile

2: triethylamine / dichloromethane

3: Grubbs catalyst first generation / dichloromethane / Reflux

4: hydrogen; 1% Pd on activated carbon / methanol

5: lithium hydroxide; water / methanol

6: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With Grubbs catalyst first generation; 1% Pd on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.001