(2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

Base Information

Chemical Name:(2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran
CAS No.:1208070-23-8
Molecular Formula:C₂₇H₂₈O₃
Molecular Weight:400.518
Hs Code.:

Synonyms:(2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

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Chemical Property of (2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

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Technology Process of (2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

There total 11 articles about (2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S)-7-(4-(benzyloxy)phenyl)-1-(4-methoxyphenyl)hepta-5,6-dien-1-ol

: 1208070-23-8
(2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In 1,2-dichloro-ethane; at 80 ℃; for 14h; diastereoselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1002/ange.202009166

Reference yield:

: 387358-62-5
5-(4-methoxyphenyl)-5-oxo-pentanal

: 1208070-23-8
(2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: copper(I) bromide / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; borane-THF / toluene / 5 h / -20 °C

4.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,1'-bis-(diphenylphosphino)ferrocene / 1,2-dichloro-ethane / 14 h / 80 °C / Inert atmosphere; Schlenk technique; Sealed tube

With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-THF; copper(I) bromide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1002/ange.202009166

Reference yield:

: 7-(4-methoxyphenyl)-7-oxohept-1-yn-3-yl acetate

: 1208070-23-8
(2R,6S)-2-((E)-4-(benzyloxy)styryl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide / tetrahydrofuran / 2 h / 0 - 20 °C

2: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; borane-THF / toluene / 5 h / -20 °C

3: chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,1'-bis-(diphenylphosphino)ferrocene / 1,2-dichloro-ethane / 14 h / 80 °C / Inert atmosphere; Schlenk technique; Sealed tube

With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-THF; copper(I) bromide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1002/ange.202009166