5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

Base Information

Chemical Name:5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester
CAS No.:216663-58-0
Molecular Formula:C₁₉H₂₃NO₅S
Molecular Weight:377.461
Hs Code.:

5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-<i>tert</i>-butyl ester

Synonyms:5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

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Chemical Property of 5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

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Technology Process of 5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

There total 1 articles about 5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 242486-38-0
4-methoxy-3-oxo-butyric acid benzyl ester

: 216663-58-0
5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

Guidance literature:: With sulfur; diethylamine; In pyridine; at 25 ℃; for 48h;
DOI:10.1016/S0040-4039(99)01108-9

Reference yield:

: 216663-58-0
5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

: 2-benzoylamino-5-isobutylcarbamoyl-4-methoxymethyl-thiophene-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: H₂ / Pd(OH)2 / ethanol

3: EDCI; HOBt; Et₃N

4: 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium dihydroxide; In ethanol; 1: Acylation / 2: Catalytic hydrogenation / 3: Esterification / 4: Substitution;
DOI:10.1016/S0040-4039(99)01108-9

Reference yield:

: 216663-58-0
5-amino-3-methoxymethyl-thiophene-2,4-dicarboxylic acid 2-benzyl ester 4-tert-butyl ester

: 5-benzylcarbamoyl-4-methoxymethyl-2-(toluene-4-sulfonylamino)-thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

2: H₂ / Pd(OH)2 / ethanol

3: EDCI; HOBt; Et₃N

4: 20 °C

5: TFA / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium dihydroxide; In ethanol; dichloromethane; 1: Acylation / 2: Catalytic hydrogenation / 3: Esterification / 4: Substitution / 5: Hydrolysis;
DOI:10.1016/S0040-4039(99)01108-9