2,3-dioxo-N-phenyl-1-indolinecarboxamide

Base Information

• Chemical Name: 2,3-dioxo-N-phenyl-1-indolinecarboxamide
• CAS No.: 53460-45-0
• Molecular Formula: C₁₅H₁₀N₂O₃
• Molecular Weight: 266.256
• Mol file: 53460-45-0.mol

Synonyms:2,3-dioxo-N-phenyl-1-indolinecarboxamide

Chemical Property of 2,3-dioxo-N-phenyl-1-indolinecarboxamide

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dioxo-N-phenyl-1-indolinecarboxamide

There total 4 articles about 2,3-dioxo-N-phenyl-1-indolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + phenyl isocyanate (103-71-9) → 2,3-dioxo-N-phenyl-1-indolinecarboxamide (53460-45-0)

Guidance literature:

With KF-Celite; In 2-methyltetrahydrofuran; for 12h; chemoselective reaction; Reflux;

DOI:10.1039/c5gc01002k

Reference yield:

hydroxyimino-N-phenylacetamide (42366-35-8,1769-41-1) → 2,3-dioxo-N-phenyl-1-indolinecarboxamide (53460-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄ / Heating

2: Et₃N / dimethylformamide / 1 h / 0 °C

With sulfuric acid; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00089a021

Reference yield:

aniline (62-53-3) → 2,3-dioxo-N-phenyl-1-indolinecarboxamide (53460-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₂OH

2: conc. H₂SO₄ / Heating

3: Et₃N / dimethylformamide / 1 h / 0 °C

With sulfuric acid; hydroxylamine; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00089a021

upstream raw materials:

indole-2,3-dione

phenyl isocyanate

hydroxyimino-N-phenylacetamide

aniline

Downstream raw materials:

indole-2,3-dione

phenyl isocyanate

(E)-ethyl 2-(2-oxo-1-(phenylcarbamoyl)indolin-3-ylidene)acetate

(E)-2-oxo-3-(2-oxopropylidene)-N-phenylindoline-1-carboxamide