1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine

Base Information

Chemical Name:1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine
CAS No.:954263-76-4
Molecular Formula:C₁₀H₁₃F₂NO₂
Molecular Weight:217.216
Hs Code.:
European Community (EC) Number:850-597-4

Synonyms:954263-76-4;1-[4-(difluoromethoxy)-3-methoxyphenyl]ethanamine;1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine;1-[4-(difluoromethoxy)-3-methoxyphenyl]ethan-1-amine;BEAWGBQBYFZGAN-UHFFFAOYSA-N;AKOS000142664;AKOS022482568;MCULE-7428754439;CS-0248078;EN300-39034;G41737;1-(4-Difluoromethoxy-3-methoxy-phenyl)-ethylamine;A1-03719;Z278080578

Suppliers and Price of 1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:217.09143498
Heavy Atom Count:15
Complexity:192

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)OC(F)F)OC)N

Technology Process of 1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine

There total 3 articles about 1-(4-Difluoromethoxy-3-methoxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101975-20-6
1-(4-(difluoromethoxy)-3-methoxyphenyl)ethan-1-one

: 954263-76-4
1-(4-difluoromethoxy-3-methoxy-phenyl)-ethylamine

Guidance literature:: With ammonia; hydrogen; nickel; In methanol; at 100 - 120 ℃; for 6h; under 30400 Torr;
DOI:10.1002/(SICI)1096-9063(1998110)54:3<223::AID-PS814>3.0.CO;2-R

Reference yield:

: 1050886-21-9
1-(4-difluoromethoxy-3-methoxy-phenyl)-ethanone oxime

: 954263-76-4
1-(4-difluoromethoxy-3-methoxy-phenyl)-ethylamine

Guidance literature:: With ammonia; hydrogen; nickel; In ethanol; at 100 ℃; for 7h; under 14710.2 Torr;
DOI:10.1002/(SICI)1096-9063(1998110)54:3<223::AID-PS814>3.0.CO;2-R

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 954263-76-4
1-(4-difluoromethoxy-3-methoxy-phenyl)-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 3 h / 100 °C

2: H₂; NH₃; Al(OH)3 / Raney nickel / methanol / 7 h / 100 °C / 14710.2 Torr

With aluminum hydroxide; ammonia; hydrogen; potassium carbonate; nickel; In methanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction;
DOI:10.1002/(SICI)1096-9063(1998110)54:3<223::AID-PS814>3.0.CO;2-R