(-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate

Base Information

• Chemical Name: (-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate
• CAS No.: 265112-69-4
• Molecular Formula: C₁₄H₁₈INO₂
• Molecular Weight: 359.207
• Mol file: 265112-69-4.mol

Synonyms:(-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate

Chemical Property of (-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate

There total 1 articles about (-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(-)-Methyl 1-Methyl-4β-phenylpiperidine-3β-carboxylate (214335-24-7) → (-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate (265112-69-4)

Guidance literature:

With perchloric acid; iodine; mercury(II) oxide; In acetic acid; at 20 ℃; for 5h;

DOI:10.1021/jm9905561

Reference yield: 79.0%

(-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate (265112-69-4) + trimethylsilylacetylene (1066-54-2) → (-)-methyl 4β-(4-ethynylphenyl)-1-methylpiperidine-3β-carboxylate

Guidance literature:

(-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate; trimethylsilylacetylene; With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; diisopropylamine; at 100 ℃; for 3h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Further stages.;

DOI:10.1021/jm9905561

Reference yield: 75.0%

allyltributylstanane (24850-33-7) + (-)-methyl 4β-(4-iodophenyl)-1-methylpiperidine-3β-carboxylate (265112-69-4) → (-)-methyl 1-methyl-4β-[4-(2-propenyl)phenyl]-piperidine-3β-carboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-tert-Butylcatechol; triphenylphosphine; In 1,4-dioxane; for 1.5h; Heating;

DOI:10.1021/jm9905561

upstream raw materials:

(-)-Methyl 1-Methyl-4β-phenylpiperidine-3β-carboxylate

Downstream raw materials:

(-)-methyl 1-methyl-4β-(4-vinylphenyl)piperidine-3β-carboxylate

(-)-methyl 4β-(4-ethylphenyl)-1-methylpiperidine-3β-carboxylate