1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

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Chemical Name:1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea
CAS No.:1610354-27-2
Molecular Formula:C₂₆H₂₆F₅N₅O₃
Molecular Weight:551.516
Hs Code.:

Synonyms:1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

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Chemical Property of 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

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Technology Process of 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

There total 5 articles about 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: (3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-amine dihydrochloride

: 1610354-61-4
5-amino-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one

: 1610354-27-2
1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

Guidance literature:: bis(trichloromethyl) carbonate; 5-amino-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

(3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-amine dihydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 22h; Reflux;

Reference yield:

: 72857-85-3
α,β-dichloro-γ-phenyl-Δ^α,β-crotonolactone

: 1610354-27-2
1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine / ethanol / 3.25 h / 20 °C / Reflux

2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

3.2: 3 h

4.1: palladium 10% on activated carbon; hydrogen / water; methanol / 20 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

5.2: 22 h / 20 °C / Reflux

With sodium azide; palladium 10% on activated carbon; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; hydrazine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 1610354-27-2
1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / 2.5 h / 20 °C

2.1: hydrazine / ethanol / 3.25 h / 20 °C / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

4.2: 3 h

5.1: palladium 10% on activated carbon; hydrogen / water; methanol / 20 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

6.2: 22 h / 20 °C / Reflux

With aluminum (III) chloride; sodium azide; palladium 10% on activated carbon; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; hydrazine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;