trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

Base Information

Chemical Name:trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester
CAS No.:1417611-58-5
Molecular Formula:C₃₉H₄₃NO₇
Molecular Weight:637.773
Hs Code.:

Synonyms:trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

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Chemical Property of trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

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Technology Process of trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

There total 3 articles about trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1989-33-9
9H-fluorene-9-carboxylic acid

: 1417611-67-6
trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-[(4-hydroxycyclohexyl)methylamino]cyclohexyl ester

: 1417611-58-5
trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 49h;
DOI:10.1016/j.bmc.2012.11.019

Reference yield:

: 4698-21-9
3-(3,4,5-trimethoxyphenyl)propiolic acid

: 1417611-58-5
trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

2.1: titanium(IV) isopropylate; sodium cyanoborohydride / 3 h / 20 °C

2.2: 20 h

3.1: formic acid; sodium hydrogencarbonate / ethanol / 4 h / 80 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

With titanium(IV) isopropylate; dmap; formic acid; sodium cyanoborohydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.11.019

Reference yield:

: 13482-22-9
4-hydroxycyclohexanone

: 1417611-58-5
trans/trans-9H-fluorene-9-carboxylic acid 4-(methyl{4-[3-(3,4,5-trimethoxyphenyl)propynoyl-oxy]cyclohexyl}amino)cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

2.1: titanium(IV) isopropylate; sodium cyanoborohydride / 3 h / 20 °C

2.2: 20 h

3.1: formic acid; sodium hydrogencarbonate / ethanol / 4 h / 80 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

With titanium(IV) isopropylate; dmap; formic acid; sodium cyanoborohydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.11.019