2-(4-Hydroxypiperidin-1-yl)benzonitrile

Base Information

Chemical Name:2-(4-Hydroxypiperidin-1-yl)benzonitrile
CAS No.:887593-80-8
Molecular Formula:C₁₂H₁₄N₂O
Molecular Weight:202.256
Hs Code.:
DSSTox Substance ID:DTXSID80591128
Wikidata:Q82484808
Mol file:887593-80-8.mol

Synonyms:887593-80-8;2-(4-hydroxypiperidin-1-yl)benzonitrile;2-(4-hydroxy-1-piperidinyl)benzonitrile;Benzonitrile,2-(4-hydroxy-1-piperidinyl)-;2-(4-HYDROXY-PIPERIDIN-1-YL)-BENZONITRILE;SCHEMBL20140119;DTXSID80591128;AKOS000260848;DB-078208;A1-79462;Z127738380

Suppliers and Price of 2-(4-Hydroxypiperidin-1-yl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
2-(4-hydroxy-piperidin-1-yl)-benzonitrile 95
25g
$ 2750.00

American Custom Chemicals Corporation
2-(4-HYDROXY-PIPERIDIN-1-YL)-BENZONITRILE 95.00%
5MG
$ 495.23

Total 3 raw suppliers

Chemical Property of 2-(4-Hydroxypiperidin-1-yl)benzonitrile

Chemical Property:

PSA：47.26000
LogP:1.58438
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:202.110613074
Heavy Atom Count:15
Complexity:250

Purity/Quality:

98% ^*data from raw suppliers

2-(4-hydroxy-piperidin-1-yl)-benzonitrile 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1O)C2=CC=CC=C2C#N

Technology Process of 2-(4-Hydroxypiperidin-1-yl)benzonitrile

There total 1 articles about 2-(4-Hydroxypiperidin-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 394-47-8
2-fluorobenzonitrile

: 887593-80-8
2-(4-hydroxypiperidin-1-yl)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 18h;

Reference yield:

: 887593-80-8
2-(4-hydroxypiperidin-1-yl)benzonitrile

: 2-(4-(5-((1-(2-cyanophenyl)piperidin-4-yl)amino)-2,4-dimethylbenzoyl)piperazin-1-yl)-3,5-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane

3: water; lithium hydroxide / methanol / 2 h / 65 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 25 °C

With water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 887593-80-8
2-(4-hydroxypiperidin-1-yl)benzonitrile

: 5-{[1-(2-cyanophenyl)piperidin-4-yl]amino}-2,4-dimethylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane

3: water; lithium hydroxide / methanol / 2 h / 65 °C

With water; sodium tris(acetoxy)borohydride; Dess-Martin periodane; lithium hydroxide; In methanol; dichloromethane;