3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591827-78-9
Molecular Formula:C₂₄H₁₅ClF₃N₅O₃
Molecular Weight:513.863
Hs Code.:

Synonyms:3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 6 articles about 3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-79-0
3-chloro-5-((1-((6-chloro-3-methoxypyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 98-80-6
phenylboronic acid

: 1591827-78-9
3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With potassium phosphate; In 1,4-dioxane; water;

Reference yield:

: 1591826-98-0
5-bromo-3-(4-methoxybenzyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one

: 1591827-78-9
3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 120 °C

2: ammonium cerium (IV) nitrate; water / acetonitrile / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; ammonium cerium (IV) nitrate; water; potassium carbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 126538-81-6
5-bromo-4-trifluoromethyl-pyrimidin-6-one

: 1591827-78-9
3-chloro-5-((1-((3-methoxy-6-phenylpyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 120 °C

3: ammonium cerium (IV) nitrate; water / acetonitrile / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

5: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; ammonium cerium (IV) nitrate; water; potassium carbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; acetonitrile;