3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

Base Information

Chemical Name:3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide
CAS No.:1351087-25-6
Molecular Formula:C₁₆H₁₈BrN₅O₃S
Molecular Weight:440.321
Hs Code.:

Synonyms:3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

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Chemical Property of 3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

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Technology Process of 3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

There total 5 articles about 3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1153284-92-4
3-amino-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

: 1351087-25-6
3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

Guidance literature:: With acetic acid; In 1,4-dioxane; at 90 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351087-25-6
3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

3.1: sodium hydride / mineral oil / 0.5 h / 20 °C

3.2: 20 °C

4.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

5.1: acetic acid / 1,4-dioxane / 24 h / 90 °C / Inert atmosphere

With chlorosulfonic acid; hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; mineral oil;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351087-25-6
3-[(5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2.1: sodium hydride / mineral oil / 0.5 h / 20 °C

2.2: 20 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

4.1: acetic acid / 1,4-dioxane / 24 h / 90 °C / Inert atmosphere

With hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; mineral oil;