(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

Base Information

Chemical Name:(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal
CAS No.:611168-50-4
Molecular Formula:C₁₈H₂₆O₂
Molecular Weight:274.403
Hs Code.:

Synonyms:(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

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Chemical Property of (S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

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Technology Process of (S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

There total 8 articles about (S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 611168-49-1
[(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pent-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

: 611168-50-4
(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

Guidance literature:: [(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pent-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine; With methyl iodide; for 3h; Heating;

With hydrogenchloride; In pentane; at 25 ℃; for 3h;
DOI:10.1002/anie.200351819

Reference yield: 91.0%

: 611168-50-4
(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

Guidance literature:

Reference yield:

: 106-25-2
Nerol

: 611168-50-4
(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 7 steps

1.1: (S,S)-2-nBu-4,5-(CONMe)2-1,3,2-dioxaborolan; Et₂Zn / 1,2-dimethoxy-ethane

2.1: 100 percent / NaH / dimethylformamide / 12 h / 0 - 25 °C

3.1: O₃ / CH₂Cl₂; methanol / -78 °C

3.2: 83 percent / NaBH₄ / CH₂Cl₂; methanol / 1 h / -78 - 25 °C

4.1: Et₃N / CH₂Cl₂ / 1 h / 25 °C

5.1: NaI / acetone / 12 h / 25 °C

6.1: LDA / tetrahydrofuran / 6 h / 0 °C

6.2: 87 percent / tetrahydrofuran / 14 h / -98 - -10 °C

7.1: MeI / 3 h / Heating

7.2: 91 percent / 3N HCl / pentane / 3 h / 25 °C

With (S,S)-2-nBu-4,5-(CONMe)2-1,3,2-dioxaborolan; diethylzinc; sodium hydride; ozone; triethylamine; sodium iodide; lithium diisopropyl amide; methyl iodide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.200351819