(Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Base Information

Chemical Name:(Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
CAS No.:1393580-84-1
Molecular Formula:C₂₀H₁₆N₂O₃
Molecular Weight:332.359
Hs Code.:

Synonyms:(Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

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Chemical Property of (Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

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Technology Process of (Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

There total 4 articles about (Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393580-76-1
ethyl (Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate

: 1393580-84-1
(Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Guidance literature:: ethyl (Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1021/jm3002718 DOI:10.1021/jm3002718

Reference yield:

: 90556-87-9
3-hydrazinylbenzoic acid ethyl ester

: 1393580-84-1
(Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 4 h / Reflux

2: ethanol / 130 °C

3: lithium hydroxide / tetrahydrofuran; water / 20 °C

With acetic acid; lithium hydroxide; In tetrahydrofuran; ethanol; water; 2: |Knoevenagel Condensation;
DOI:10.1021/jm3002718 DOI:10.1021/jm3002718

Reference yield:

: 354997-99-2
ethyl 3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-benzoate

: 1393580-84-1
(Z)-3-(4-((E)-3-phenylallylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 130 °C

2: lithium hydroxide / tetrahydrofuran; water / 20 °C

With lithium hydroxide; In tetrahydrofuran; ethanol; water; 1: |Knoevenagel Condensation;
DOI:10.1021/jm3002718 DOI:10.1021/jm3002718