1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate
CAS No.:1093631-65-2
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

There total 5 articles about 1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1093631-64-1
1-(1,1-dimethylethyl) 2-ethyl 5-{[(trifluoromethyl)sulfonyl]oxy}-1H-indole-1,2-dicarboxylate

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1093631-65-2
1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: With potassium phosphate; water; triphenylphosphine; palladium diacetate; In 1,4-dioxane; at 130 ℃; for 1h; Sealed tube;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1093631-65-2
1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / tetrahydrofuran / 1.5 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol; chloroform / 1 h / 20 °C

3: triethylamine / dichloromethane / 0.33 h / 0 °C

4: potassium phosphate; water; triphenylphosphine / palladium diacetate / 1,4-dioxane / 1 h / 130 °C / Sealed tube

With dmap; potassium phosphate; water; hydrogen; triethylamine; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; 4: Suzuki Coupling;

Reference yield:

: 37033-95-7
5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 1093631-65-2
1-(1,1-dimethylethyl) 2-ethyl 5-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / tetrahydrofuran / 1.5 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol; chloroform / 1 h / 20 °C

3: triethylamine / dichloromethane / 0.33 h / 0 °C

4: potassium phosphate; water; triphenylphosphine / palladium diacetate / 1,4-dioxane / 1 h / 130 °C / Sealed tube

With dmap; potassium phosphate; water; hydrogen; triethylamine; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; 4: Suzuki Coupling;