2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1610033-40-3
Molecular Formula:C₂₄H₂₅F₄N₃O₂
Molecular Weight:463.475
Hs Code.:

Synonyms:2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

There total 16 articles about 2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1610033-39-0
1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl 4-methylbenzenesulfonate

: 1610033-08-3
2-((2R,4R)-1-(4-hydroxyphenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 1610033-40-3
2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 15h;

Reference yield:

: 1610033-38-9
1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-ol

: 1610033-40-3
2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 5 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 55 °C

With dmap; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1610033-07-2
2-((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 1610033-40-3
2-((2R,4R)-1-(4-((1-(2-fluoro-5-methoxyphenyl)pyrrolidin-3-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 72 h / 20 °C / 760.05 Torr / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 55 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In ethyl acetate; N,N-dimethyl-formamide;