(5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

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Chemical Name:(5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one
CAS No.:1447589-61-8
Molecular Formula:C₃₁H₃₂N₄O₄
Molecular Weight:524.619
Hs Code.:

Synonyms:(5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

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Chemical Property of (5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

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Technology Process of (5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

There total 4 articles about (5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1447589-60-7
(S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)indolo[2,1-b]quinazolin-12(6H)-one

: 1447589-61-8
(5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

Guidance literature:: With sodium tetrahydroborate; acetic acid; at 20 ℃; for 2h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ol401709t

Reference yield:

: 13220-57-0
tryptanthrine

: 1447589-61-8
(5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: acetic acid; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ol401709t

Reference yield:

: 118-48-9
isatoic anhydride

: 1447589-61-8
(5aS,6S)-6-hydroxy-6-(2-((S)-5-isopropyl-2-oxo-3-((R)-1-phenylethyl)imidazolidin-1-yl)-2-oxoethyl)-5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / toluene / 2 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: acetic acid; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1021/ol401709t