ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate

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Chemical Name:ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate
CAS No.:1477518-50-5
Molecular Formula:C₁₇H₂₁N₃O₃
Molecular Weight:315.372
Hs Code.:

Synonyms:ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate

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Chemical Property of ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate

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Technology Process of ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate

There total 2 articles about ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₁₆IN₃O₃

: 98-80-6
phenylboronic acid

: 1477518-50-5
ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; In tetrahydrofuran; at 70 ℃; for 8h; Inert atmosphere;
DOI:10.2174/1386207311316080009

Reference yield:

: 181945-29-9
tetrahydropyranmethyl azide

: 1477518-50-5
ethyl 5-phenyl-1-((tetrahydro-2H-pyran-2yl)methyl)-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Iodine monochloride; triethylamine; copper(l) chloride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / tetrahydrofuran / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; Iodine monochloride; triethylamine; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; 1: |Huisgen Cycloaddition / 2: |Suzuki Coupling;
DOI:10.2174/1386207311316080009