3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Base Information

• Chemical Name: 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide
• CAS No.: 1448316-14-0
• Molecular Formula: C₂₅H₁₇F₅N₆OS
• Molecular Weight: 544.508

Synonyms:3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Chemical Property of 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

There total 3 articles about 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyano-5-(pentafluoro-λ6-sulphanyl)benzoic acid (1448317-58-5) + 2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline (1448318-33-9) → 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ6-sulphanyl)benzamide (1448316-14-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

3-(pentafluoro-λ6-sulphanyl)benzoic acid (833-96-5) → 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ6-sulphanyl)benzamide (1448316-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; trifluoroacetic acid; N-Bromosuccinimide / 18 h / 50 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

3-bromo-5-(pentafluoro-λ6-sulphanyl)benzoic acid (1180675-98-2) → 3-cyano-N-{2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ6-sulphanyl)benzamide (1448316-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

upstream raw materials:

3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

3-bromo-5-(pentafluoro-λ⁶-sulphanyl)benzoic acid

3-cyano-5-(pentafluoro-λ⁶-sulphanyl)benzoic acid

2-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

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