α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol

Base Information

• Chemical Name: α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol
• CAS No.: 83193-50-4
• Molecular Formula: C₂₀H₂₄FNOS
• Molecular Weight: 345.481
• Mol file: 83193-50-4.mol

Synonyms:α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol

Chemical Property of α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol

There total 3 articles about α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluorothiophenol (2557-78-0) → α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol (83193-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / aq. NaOH / hexamethylphosphoric acid triamide / 3.5 h / 100 °C

2: Mg / tetrahydrofuran, reflux 3 h

With sodium hydroxide; magnesium; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1135/cccc19821367

Reference yield:

2-chloro-benzaldehyde (89-98-5) → α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol (83193-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / aq. NaOH / hexamethylphosphoric acid triamide / 3.5 h / 100 °C

2: Mg / tetrahydrofuran, reflux 3 h

With sodium hydroxide; magnesium; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1135/cccc19821367

Reference yield:

3-(chloromethyl)-1-methylpiperidine (52694-50-5) + 2-(2-Fluorophenylthio)benzaldehyde (83193-43-5) → α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol (83193-50-4)

Guidance literature:

With magnesium; Yield given. Multistep reaction; tetrahydrofuran, reflux 3 h;

DOI:10.1135/cccc19821367

upstream raw materials:

3-(chloromethyl)-1-methylpiperidine

2-(2-Fluorophenylthio)benzaldehyde

2-fluorothiophenol

2-chloro-benzaldehyde

Downstream raw materials:

1-<2-(2-hydroxyphenylthio)phenyl>-2-(1-methyl-3-piperidyl)ethene

6-(1-Methyl-3-piperidylmethyl)-6H-dibenz-1,4-oxathiepin