ethyl 2-phenyl-2-(p-tolylamino)acetateacetate

Base Information

• Chemical Name: ethyl 2-phenyl-2-(p-tolylamino)acetateacetate
• CAS No.: 5667-75-4
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 5667-75-4.mol

Synonyms:ethyl 2-phenyl-2-(p-tolylamino)acetateacetate

Chemical Property of ethyl 2-phenyl-2-(p-tolylamino)acetateacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-phenyl-2-(p-tolylamino)acetateacetate

There total 4 articles about ethyl 2-phenyl-2-(p-tolylamino)acetateacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 2-phenyldiazoacetate (22065-57-2) + p-toluidine (106-49-0,12221-03-3) → ethyl 2-phenyl-2-(p-tolylamino)acetateacetate (5667-75-4)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol800087p

Reference yield: 63.0%

ethyl 2-(dimethyl(oxo)- λ6-sulfaneylidene)-2-phenylacetate + p-toluidine (106-49-0,12221-03-3) → ethyl 2-phenyl-2-(p-tolylamino)acetateacetate (5667-75-4)

Guidance literature:

With nitric acid; In water; at 35 ℃; for 24h;

DOI:10.1055/s-0040-1707186

Reference yield:

Ethyl 2-phenylethanoate (101-97-3) → ethyl 2-phenyl-2-(p-tolylamino)acetateacetate (5667-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

2: palladium dichloride / 1,2-dichloro-ethane / 9 h / 20 - 40 °C / Inert atmosphere; Schlenk technique

With 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium dichloride; In 1,2-dichloro-ethane; acetonitrile;

DOI:10.1039/c3ob41331d

upstream raw materials:

ethyl 2-phenyldiazoacetate

p-toluidine

Ethyl 2-phenylethanoate

Downstream raw materials:

benzoic acid ethyl ester