(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

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Chemical Name:(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride
CAS No.:1422052-00-3
Molecular Formula:C₂₄H₂₄ClF₂N₅O₄S₂
Molecular Weight:584.067
Hs Code.:

Synonyms:(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

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Chemical Property of (S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

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Technology Process of (S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

There total 10 articles about (S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422051-99-7
(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonic acid

: 1422052-00-3
(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1422051-97-5
(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutyl methanesulfonate

: 1422052-00-3
(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 1 h / 80 °C

2: formic acid; dihydrogen peroxide / water / 2 h / 0 - 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

With formic acid; oxalyl dichloride; dihydrogen peroxide; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1422051-98-6
(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutyl ethanethioate

: 1422052-00-3
(S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid; dihydrogen peroxide / water / 2 h / 0 - 20 °C

2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

With formic acid; oxalyl dichloride; dihydrogen peroxide; In dichloromethane; water; N,N-dimethyl-formamide;