butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

Base Information

Chemical Name:butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate
CAS No.:1392437-91-0
Molecular Formula:C₃₃H₄₉NO₅Si
Molecular Weight:567.841
Hs Code.:

Synonyms:butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

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Chemical Property of butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

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Technology Process of butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

There total 3 articles about butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: butyl (2S,6S,E)-6-(tert-butyldimethylsilyloxy)-2-[(1R)-(1-phenylethyl)amino]hept-4-enoate

: 1392437-91-0
butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

Guidance literature:: With potassium carbonate; In chloroform; for 16h; Inert atmosphere; Reflux;
DOI:10.1039/c2ob25097g

Reference yield:

: (4S)-4-(tertbutyldimethylsilyloxy)pent-2-enyl(tributyl)stannane

: 1392437-91-0
butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(IV) chloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

1.2: 12 h / -45 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: potassium carbonate / chloroform / 16 h / Inert atmosphere; Reflux

With tin(IV) chloride; potassium carbonate; In dichloromethane; chloroform;
DOI:10.1039/c2ob25097g

Reference yield:

: 67321-49-7
C₁₄H₁₉NO₂

: 1392437-91-0
butyl (2S,6S,E)-2-{benzyloxycarbonyl[(1R)-(1-phenylethyl)]-amino}-6-(tert-butyldimethylsilyloxy)hept-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(IV) chloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

1.2: 12 h / -45 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: potassium carbonate / chloroform / 16 h / Inert atmosphere; Reflux

With tin(IV) chloride; potassium carbonate; In dichloromethane; chloroform;
DOI:10.1039/c2ob25097g