(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

Base Information

Chemical Name:(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate
CAS No.:1383006-45-8
Molecular Formula:C₂HF₃O₂*C₂₃H₂₄N₂O₆
Molecular Weight:538.477
Hs Code.:

Synonyms:(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

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Chemical Property of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

Chemical Property:

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Technology Process of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

There total 9 articles about (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13626-60-3
3-hydroxy-1,2-oxazole-5-carboxylic acid

: (2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester hydrochloride

: 76-05-1
trifluoroacetic acid

: 1383006-45-8
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

Guidance literature:: 3-hydroxy-1,2-oxazole-5-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;

(2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 1038924-77-4
(S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

: 1383006-45-8
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h

4.1: hydrogenchloride / water / 20 h / 90 - 95 °C

5.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h

5.2: 20 °C

With hydrogenchloride; n-butyllithium; 1-hydroxy-7-aza-benzotriazole; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexanes; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1383006-45-8
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 3 h / -5 °C

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -65 °C / Inert atmosphere

4.2: 2 h / -35 °C

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 2.25 h / 0 °C

6.1: potassium carbonate / 20 h / 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol / 3 h / 25 °C

8.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h

8.2: 20 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;