N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Base Information

• Chemical Name: N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine
• CAS No.: 1578245-44-9
• Molecular Formula: C₂₄H₃₀N₈O
• Molecular Weight: 446.555

Synonyms:N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Chemical Property of N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

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Technology Process of N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

There total 9 articles about N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)formamide (1578247-07-0) + 6-methyl-2-(methylsulfonyl)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine (1578246-25-9) → N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (1578245-44-9)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 120 ℃; for 18h;

DOI:10.1021/acs.jmedchem.8b00690

Reference yield:

2.2-dimethylpropylamine (5813-64-9) → N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (1578245-44-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 100 - 130 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

3: caesium carbonate / dimethyl sulfoxide / 18 h / 120 °C

With caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.8b00690

Reference yield:

4-bromo-2-ethoxy-1-nitro-benzene (57279-70-6) → N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (1578245-44-9)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; 2,2-dimethylbutyric acid / toluene / 18 h / 140 °C / Darkness

2: palladium 10% on activated carbon; hydrogen / ethanol / 18 h

3: 1.5 h / 100 °C

4: caesium carbonate / dimethyl sulfoxide / 18 h / 120 °C

With 2,2-dimethylbutyric acid; palladium 10% on activated carbon; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate; In ethanol; dimethyl sulfoxide; toluene;

DOI:10.1021/acs.jmedchem.8b00690

upstream raw materials:

4-bromo-2-ethoxy-1-nitro-benzene

2.2-dimethylpropylamine

6-methyl-2-(methylthio)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine

3-ethoxy-4-nitro-benzoic acid

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