4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide
CAS No.:1232233-72-5
Molecular Formula:C₂₃H₂₃ClN₆OS
Molecular Weight:466.994
Hs Code.:

Synonyms:4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

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Chemical Property of 4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

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Technology Process of 4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

There total 12 articles about 4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232234-51-3
4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5 carboxylic acid

: 1232233-72-5
4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Guidance literature:: With ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1232234-46-6
4-(3-chloro-phenyl)-2-(6-formyl-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

: 1232233-72-5
4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Guidance literature:: 1-methyl-piperazine; 4-(3-chloro-phenyl)-2-(6-formyl-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 24h;

With water; ammonium chloride; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 160538-51-2
3-fluoro-4-nitro-benzaldehyde

: 1232233-72-5
4-(3-chloro-phenyl)-2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / methanol / 1 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3.1: hydrogenchloride; water / acetonitrile / 2 h / 60 °C

4.1: hydrogenchloride; zinc / tetrahydrofuran; water / 0.75 h / 20 °C

5.1: acetic acid / 0.5 h / 20 °C / Inert atmosphere

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C

6.2: 0.5 h / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; zinc; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;