7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid

Base Information

• Chemical Name: 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid
• CAS No.: 131580-85-3
• Molecular Formula: C₃₀H₂₅ClN₂O₅S
• Molecular Weight: 561.058
• Mol file: 131580-85-3.mol

Synonyms:7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid

Chemical Property of 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid

There total 8 articles about 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

7-Phenylacetamido-3-(1-chlorethenyl)-2-cephem-4-carbonsaeure-benzhydrylester (131580-84-2) → 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid (131580-85-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 - 25 ℃; for 2h;

DOI:10.1002/ardp.19913240213

Reference yield:

(6R)-3-acetoxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid (879661-66-2) → 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid (131580-85-3)

Guidance literature:

Multi-step reaction with 5 steps

1: LiOH

2: 1.) Chrom(VI)-oxid, H₂SO₄

3: 2.) Chrom(VI)-oxid, H₂SO₄

4: 15 percent / CCl₄, Ph₃P / 24 h / 78 °C

5: 55 percent / MCPBA / CH₂Cl₂ / 2 h / 20 - 25 °C

With chromium(VI) oxide; tetrachloromethane; lithium hydroxide; sulfuric acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In dichloromethane;

DOI:10.1002/ardp.19913240213

Reference yield:

3-formyl-7β-phenylacetylamino-ceph-2-em-4α-carboxylic acid diphenylmethyl ester (39914-26-6,92009-15-9) → 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid (131580-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) Chrom(VI)-oxid, H₂SO₄

2: 15 percent / CCl₄, Ph₃P / 24 h / 78 °C

3: 55 percent / MCPBA / CH₂Cl₂ / 2 h / 20 - 25 °C

With chromium(VI) oxide; tetrachloromethane; sulfuric acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In dichloromethane;

DOI:10.1002/ardp.19913240213

upstream raw materials:

7-Phenylacetamido-3-(1-chlorethenyl)-2-cephem-4-carbonsaeure-benzhydrylester

(6R)-3-acetoxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid

3-formyl-7β-phenylacetylamino-ceph-2-em-4α-carboxylic acid diphenylmethyl ester

diphenylmethyl 7-phenylacetamido-3-acetyl-2-cephem-4-carboxylate

Downstream raw materials:

7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester

7-<<(2-Amino4-thiazolyl)(methoxyimino)acetyl>amino>-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester

7-Amino-3-(1-chlorethenyl)-3-cephem-4-carbonsaeurebenzhydrylester-hydrochlorid