methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

Base Information

Chemical Name:methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate
CAS No.:1616373-05-7
Molecular Formula:C₃₅H₄₁F₂N₃O₄
Molecular Weight:605.725
Hs Code.:

Synonyms:methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

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Chemical Property of methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

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Technology Process of methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

There total 10 articles about methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1454928-36-9
methyl 2-(2-ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

: 1616373-03-5
3-(3-(3-bromophenyl)-3,3-difluoropropyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

: 1616373-05-7
methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 1616372-97-4
4-(3-bromophenyl)-4,4-difluorobutanenitrile

: 1616373-05-7
methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / ethylene glycol / 16 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

2.2: 16 h / 20 °C

3.1: camphor-10-sulfonic acid / ethyl acetate / 16 h / Reflux

4.1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In 1,4-dioxane; water; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1616373-01-3
2-(4-(3-bromophenyl)-4,4-difluorobutanoyl)-1-(4-(tert-butyl)benzyl)-N-ethylhydrazinecarboxamide

: 1616373-05-7
methyl 2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,1-difluoropropyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / ethyl acetate / 16 h / Reflux

2: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium hydrogencarbonate; In 1,4-dioxane; water; ethyl acetate;