5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

Base Information

Chemical Name:5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine
CAS No.:330551-06-9
Molecular Formula:C₁₉H₂₆N₆O
Molecular Weight:354.455
Hs Code.:

Synonyms:5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

Chemical Property:

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Technology Process of 5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

There total 6 articles about 5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414781-18-2
N⁴-cyclopentyl-N²-(4-morpholinophenyl)-5-nitropyrimidine-2,4-diamine hydrochloride

: 330551-06-9
5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 6h; under 760.051 Torr;
DOI:10.1021/jm301365e

Reference yield:

: N₄-cyclopentyl-N₂-(4-morpholinophenyl)-5-nitro-2,4-diaminepyrimidine

: 330551-06-9
5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 70 ℃;
DOI:10.1016/j.bmcl.2021.128213

Reference yield:

: 330550-92-0
2-chloro-N-cyclopentyl-5-nitropyrimidin-4-amine

: 330551-06-9
5-amino-4-(cyclopentylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: butan-1-ol / 5 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; In methanol; butan-1-ol;
DOI:10.1021/jm301365e