4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose

Base Information

• Chemical Name: 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose
• CAS No.: 105283-45-2
• Molecular Formula: C₂₉H₂₇NO₆
• Molecular Weight: 485.536
• Mol file: 105283-45-2.mol

Synonyms:4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose

Chemical Property of 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose

There total 6 articles about 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acetic anhydride (108-24-7) + 3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose (105313-37-9) → 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose (105283-45-2)

Guidance literature:

With pyridine; at 20 ℃; for 20h;

DOI:10.1007/BF00952870

Reference yield:

bromo-2,3,4-O-triacetyl-α/β-L-arabinopyranoside (51830-02-5) → 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose (105283-45-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.64 g / Bu₄NBr / acetonitrile / 65 h

2: 81 percent / MeONa / methanol / 0.5 h / 20 °C

3: 17.5 percent / 2,4,6-collidine / CH₂Cl₂ / 1 h / 20 °C

4: 91 percent / pyridine / 20 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; tetrabutylammomium bromide; sodium methylate; In methanol; dichloromethane; acetonitrile;

DOI:10.1007/BF00952870

Reference yield:

triphenylmethyl perchlorate → 4-O-acetyl-3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose (105283-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.5 percent / 2,4,6-collidine / CH₂Cl₂ / 1 h / 20 °C

2: 91 percent / pyridine / 20 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; In dichloromethane;

DOI:10.1007/BF00952870

upstream raw materials:

acetic anhydride

3-O-trityl-1,2-O-<1-(exo-cyano)ethylidene>-β-L-arabinopyranose

bromo-2,3,4-O-triacetyl-α/β-L-arabinopyranoside

1,2,3,4-tetra-O-acetyl-L-arabinopyranose