5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride

Base Information

• Chemical Name: 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride
• CAS No.: 70959-79-4
• Molecular Formula: C₁₉H₂₆N₂O₆S*ClH
• Molecular Weight: 446.952
• Mol file: 70959-79-4.mol

Synonyms:5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride

Chemical Property of 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride

There total 7 articles about 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

5-(2-{Benzyl-[2-(2-methoxy-phenoxy)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-2-methoxy-benzenesulfonamide (344756-93-0) → 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride (70959-79-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1248/cpb.30.4092

Reference yield:

1-(2-methoxyphenoxy)propan-2-one (6437-46-3) → 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride (70959-79-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / H₂ / PtO₂ / methanol

2: butan-2-one / 4 h / Heating

3: NaBH₄ / methanol / 2 h / Ambient temperature

4: 36 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; palladium on activated charcoal; In methanol; butanone;

DOI:10.1248/cpb.30.4092

Reference yield:

5-acetyl-2-methoxybenzenesulfonamide (85276-46-6) → 5-{1-Hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-2-methoxy-benzenesulfonamide; hydrochloride (70959-79-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

2: butan-2-one / 4 h / Heating

3: NaBH₄ / methanol / 2 h / Ambient temperature

4: 36 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; bromine; palladium on activated charcoal; In methanol; acetic acid; butanone;

DOI:10.1248/cpb.30.4092

upstream raw materials:

5-(2-{Benzyl-[2-(2-methoxy-phenoxy)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-2-methoxy-benzenesulfonamide

1-(2-methoxyphenoxy)propan-2-one

5-acetyl-2-methoxybenzenesulfonamide

1-(3-amino-4-methoxyphenyl)ethan-1-one