N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

Base Information

Chemical Name:N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline
CAS No.:711029-84-4
Molecular Formula:C₂₅H₃₅N₃O₃S
Molecular Weight:457.637
Hs Code.:

Synonyms:N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

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Chemical Property of N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

Chemical Property:

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Technology Process of N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

There total 7 articles about N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 333795-01-0
4-{[4-(4-Piperidinylmethyl)phenyl]sulfonyl}morpholine

: N-(3-chloropropyl)aniline hydrochloride

: 711029-84-4
N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile; at 100 ℃; for 6h;
DOI:10.1016/j.bmc.2004.02.004

Reference yield:

: 31252-42-3
4-benzylpyperidine

: 711029-84-4
N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / ethyl acetate / 3 h / 20 °C

2: 65 percent / chlorosulfonic acid / CH₂Cl₂ / 5 h / 20 °C

3: 95 percent / triethylamine / tetrahydrofuran / 2 h / 20 °C

4: 100 percent / K₂CO₃ / methanol; H₂O / 12 h / 20 °C

5: 88 percent / potassium iodide; potassium carbonate / acetonitrile; dimethylformamide / 6 h / 100 °C

With chlorosulfonic acid; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2004.02.004

Reference yield:

: 13268-47-8
N-(3-chloropropyl)-N-phenylformamide

: 711029-84-4
N-(3-{4-[4-(morpholin-4-ylsulfonyl)benzyl]piperidin-1-yl}propyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / hydrochloric acid / propan-2-ol / 5 h / 60 °C

2: 88 percent / potassium iodide; potassium carbonate / acetonitrile; dimethylformamide / 6 h / 100 °C

With hydrogenchloride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2004.02.004