3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

Base Information

Chemical Name:3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate
CAS No.:1259017-53-2
Molecular Formula:C₃₀H₃₀ClFN₄O₄S₂
Molecular Weight:629.176
Hs Code.:

Synonyms:3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

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Chemical Property of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

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Technology Process of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

There total 8 articles about 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 110-91-8,99108-56-2
morpholine

: 75-15-0,12122-00-8
carbon disulfide

: 1259017-73-6
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine

: 1259017-53-2
3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

Guidance literature:: morpholine; With potassium phosphate; In N,N-dimethyl-formamide; for 0.25h;

carbon disulfide; In N,N-dimethyl-formamide; for 0.5h;

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 692059-41-9
6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline

: 1259017-53-2
3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 3 h / Reflux

2.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

With potassium phosphate; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 574738-93-5
6-(3-chloropropoxy)-7-methoxyquinazolin-4-ol

: 1259017-53-2
3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2.1: triethylamine / isopropyl alcohol / 3 h / Reflux

3.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

3.2: 0.5 h

With potassium phosphate; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.04.096