(E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone

Base Information

Chemical Name:(E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone
CAS No.:1026861-91-5
Molecular Formula:C₂₆H₂₆F₂N₂O₂S
Molecular Weight:468.567
Hs Code.:

Synonyms:(E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone

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Chemical Property of (E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone

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Technology Process of (E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone

There total 1 articles about (E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124-65-8,15690-25-2,51019-83-1
3-(2-thienyl)-2-propenoic acid

: 61897-33-4
1-[2-(bis(4-fluorophenyl)methoxy)ethyl]piperazine

: 1026861-91-5
(E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) CH₂Cl₂, THF, RT, 30 min, 2.) CH₂Cl₂, THF, 24 h;
DOI:10.1021/jm9606599

Reference yield:

: 1026861-91-5
(E)-1-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-3-thiophen-2-yl-propenone

: 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-thiophen-2-yl-propyl)-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum hydride / tetrahydrofuran / 0.17 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 36 h / 2327.2 Torr

With aluminium hydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9606599