5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester
CAS No.:1052112-06-7
Molecular Formula:C₁₈H₂₄O₄
Molecular Weight:304.386
Hs Code.:

Synonyms:5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

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Technology Process of 5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

There total 6 articles about 5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 616-38-6
carbonic acid dimethyl ester

: 228552-99-6
4-[2-(4-methoxy-phenyl)-ethyl]-4-methyl-cyclohexanone

: 1052112-06-7
5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With sodium hydride; for 0.75h; Heating;
DOI:10.1016/S0040-4039(99)00658-9

Reference yield:

: 38954-00-6
1-iodo-2-(4-methoxyphenyl)ethane

: 1052112-06-7
5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: lithium diisopropylamide / tetrahydrofuran / 16 h / -78 - -10 °C

2: lithium diisopropylamide / tetrahydrofuran / 16 h / Ambient temperature

3: 86 percent / 1.) lithium aluminum hydride; 2.) 10 percent hydrochloric acid / diethyl ether / 1.) 0 deg C, 0.5 h; 2.) 2 h

4: 91 percent / hydrogen / Pd/C / ethyl acetate / 3 h / 1520 Torr

5: 90 percent / sodium hydride / 0.75 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate;
DOI:10.1016/S0040-4039(99)00658-9

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 1052112-06-7
5-[2-(4-methoxy-phenyl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: lithium diisopropylamide / tetrahydrofuran / 16 h / -78 - -10 °C

2: lithium diisopropylamide / tetrahydrofuran / 16 h / Ambient temperature

3: 86 percent / 1.) lithium aluminum hydride; 2.) 10 percent hydrochloric acid / diethyl ether / 1.) 0 deg C, 0.5 h; 2.) 2 h

4: 91 percent / hydrogen / Pd/C / ethyl acetate / 3 h / 1520 Torr

5: 90 percent / sodium hydride / 0.75 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate;
DOI:10.1016/S0040-4039(99)00658-9