1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Base Information

Chemical Name:1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione
CAS No.:1308721-94-9
Molecular Formula:C₂₀H₂₆N₂O₈
Molecular Weight:422.435
Hs Code.:

Synonyms:1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

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Chemical Property of 1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

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Technology Process of 1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

There total 8 articles about 1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-acetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

: 108-24-7
acetic anhydride

: 1308721-94-9
1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Guidance literature:: With pyridine; dmap; at 25 ℃; for 2.5h;
DOI:10.1016/j.tetlet.2011.02.055

Reference yield:

: 1308721-86-9
2-hydroxy-3-methyl-4,5-dimethoxybenzaldehyde

: 1308721-94-9
1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide

1.2: 2 h / 25 °C

2.1: potassium tert-butylate / dichloromethane; tert-butyl alcohol / 1 h / 25 °C

3.1: 5% Rh/C; hydrogen / isopropyl alcohol / 14 h / 25 °C

4.1: pyridine; dmap / 2.5 h / 25 °C

With pyridine; dmap; 5% Rh/C; potassium tert-butylate; hydrogen; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.055

Reference yield:

: 1308721-90-5
4,5-dimethoxy-2-(methoxymethoxy)-3-methylbenzaldehyde

: 1308721-94-9
1,4-diacetyl-3-[(4,5-dimethoxy-2-methoxymethoxy-3-methylphenyl)methyl]piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / dichloromethane; tert-butyl alcohol / 1 h / 25 °C

2: 5% Rh/C; hydrogen / isopropyl alcohol / 14 h / 25 °C

3: pyridine; dmap / 2.5 h / 25 °C

With pyridine; dmap; 5% Rh/C; potassium tert-butylate; hydrogen; In dichloromethane; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.055