4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

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Chemical Name:4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene
CAS No.:250696-15-2
Molecular Formula:C₁₆H₃₁NO₂Si
Molecular Weight:297.513
Hs Code.:

Synonyms:4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

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Chemical Property of 4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

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Technology Process of 4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

There total 1 articles about 4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 250696-15-2
4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / CH₂Cl₂ / 3 h / 20 °C

2.1: KHMDS / toluene; tetrahydrofuran / 3 h / -78 - -30 °C

2.2: 94 percent / toluene; tetrahydrofuran / -78 - 20 °C

With potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; toluene; 1.1: Condensation / 2.1: Metallation / 2.2: Condensation;
DOI:10.1021/ja9921930

Reference yield: 100.0%

: 78-85-3,25120-30-3
2-methylpropenal

: 250696-15-2
4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

: 4-(tert-butyl-dimethyl-silanyloxy)-2-(2-methoxymethyl-pyrrolidin-1-yl)-1-methyl-cyclohex-3-enecarbaldehyde

Guidance literature:: In toluene; a) -20 deg C, 30 min, b) RT, 22 h;
DOI:10.1021/ja9921930

Reference yield:

: 250696-15-2
4-(2-(S)-methoxymethyl-pyrrolidin-1-yl)-3-(tert-butyldimethylsiloxy)-1,3-butadiene

: [4-(tert-butyl-dimethyl-silanyloxy)-2-(2-methoxymethyl-pyrrolidin-1-yl)-1-methyl-cyclohex-3-enyl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / toluene / a) -20 deg C, 30 min, b) RT, 22 h

2: LiAlH₄ / diethyl ether / 2 h / -78 °C

With lithium aluminium tetrahydride; In diethyl ether; toluene; 1: Diels-Alder reaction / 2: Reduction;
DOI:10.1021/ja9921930