N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

Base Information

Chemical Name:N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine
CAS No.:359011-72-6
Molecular Formula:C₂₅H₃₅NO₄
Molecular Weight:413.557
Hs Code.:

Synonyms:N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

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Chemical Property of N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

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Technology Process of N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

There total 5 articles about N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 359011-68-0
[3S,4S,5S,6S]-N-[4,5-dibenzyloxy-3,6-di-tert-butyl(dimethyl)silyloxycycloheptanyl]-N-butylamine

: 359011-72-6
N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0040-4039(01)00756-0

Reference yield:

: 243978-64-5
[3S,4S,5S,6S]-4,5-dibenzyloxy-3,6-di-tert-butyl(dimethyl)silyloxycycloheptan-1-one

: 359011-72-6
N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

Guidance literature:: Multi-step reaction with 3 steps

1: Ti(OiPr)4 / ethanol / 2 h / 20 °C

2: sodium cyanoborohydride / ethanol / 14 h / 20 °C

3: 85 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 24 h / 20 °C

With titanium(IV) isopropylate; tetrabutyl ammonium fluoride; sodium cyanoborohydride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2003.09.049

Reference yield:

: 243978-56-5
[3S,4S,5S,6S]-4,5-dibenzyloxy-3,6-di-tert-butyl(dimethyl)silyloxycycloheptan-1-one 1,3-propanedithioketal

: 359011-72-6
N-([3S,4R,5R,6S]-4,5-di-O-benzyl-3,4,5,6-tetrahydroxycycloheptanyl)-N-butylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / N-bromosuccinimide / acetone; H₂O / 0.5 h / -25 °C

2: Ti(OiPr)4 / ethanol / 2 h / 20 °C

3: sodium cyanoborohydride / ethanol / 14 h / 20 °C

4: 85 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 24 h / 20 °C

With titanium(IV) isopropylate; N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium cyanoborohydride; In tetrahydrofuran; ethanol; water; acetone;
DOI:10.1016/j.tet.2003.09.049