N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

Base Information

Chemical Name:N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride
CAS No.:634903-62-1
Molecular Formula:C₂₄H₂₂N₄O₂S*ClH
Molecular Weight:466.991
Hs Code.:

Synonyms:N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

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Chemical Property of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

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Technology Process of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

There total 9 articles about N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide

: 634903-62-1
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

: 550999-97-8
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-cyano-1-benzothiopene-2-carboxamide

: 634903-62-1
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol

2.1: hydroxylamine hydrochloride; potassium carbonate / ethanol; water / 3 h / 80 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol

4.1: sodium hydride / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 0.83 h / 20 - 60 °C

4.2: 38 h / 70 - 80 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); ethanol; water;

Reference yield:

: 6-[(Z)-amino(hydroxyimino)methyl]-N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzothiophene-2-carboxamide dihydrochloride

: 634903-62-1
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(5-phenyl-1,2,4-oxadiazol-3-yl)-1-benzothiophene-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 0.83 h / 20 - 60 °C

1.2: 38 h / 70 - 80 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide);