tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate
CAS No.:1283128-42-6
Molecular Formula:C₂₈H₃₈N₄O₆S
Molecular Weight:558.699
Hs Code.:

Synonyms:tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

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Chemical Property of tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

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Technology Process of tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

There total 15 articles about tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1221179-29-8
tert-butyl (R)-6-[2-[N-((2-(3-aminophenyl)-2-((triethylsilyl)oxy)ethyl)-N-(tert-butoxycarbonyl)amino)]ethoxy]-3-methyl-1H-indazole-1-carboxylate

: 26394-17-2
cyclopentanesulfonyl chloride

: 1283128-42-6
tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

Guidance literature:: tert-butyl (R)-6-[2-[N-((2-(3-aminophenyl)-2-((triethylsilyl)oxy)ethyl)-N-(tert-butoxycarbonyl)amino)]ethoxy]-3-methyl-1H-indazole-1-carboxylate; cyclopentanesulfonyl chloride; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

With sodium hydroxide; In methanol; at 20 ℃; for 72h;

With hydrogenchloride; In water; at 20 ℃;
DOI:10.1021/acs.jmedchem.6b01197

Reference yield:

: C₃₉H₆₀N₄O₈SSi

: 1283128-42-6
tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

Guidance literature:: C₃₉H₆₀N₄O₈SSi; With water; sodium hydroxide; In methanol; at 20 ℃; for 60h;

With ammonium chloride; In methanol;

Reference yield:

: 1221179-26-5
(R)-N-benzyl-N-(2-(benzyloxy)ethyl)-2-(3-nitrophenyl)-2-((triethylsilyl)oxy)ethan-1-amine

: 1283128-42-6
tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 13 h / 50 °C

1.2: 1.5 h / 20 °C

1.3: 8 h / 50 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 36 h / 20 °C

4.1: sodium hydroxide; water / methanol / 60 h / 20 °C

With di-isopropyl azodicarboxylate; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; toluene;