N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Base Information

Chemical Name:N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide
CAS No.:1569314-83-5
Molecular Formula:C₂₀H₂₁N₃O₉S
Molecular Weight:479.467
Hs Code.:

Synonyms:N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Suppliers and Price of N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

There total 7 articles about N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1569314-57-3
3-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)propanoic acid

: 1569314-83-5
N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: 3-(1,1-dioxido-3-oxo-6-(3,4,5-trimethoxybenzamido)benzo[d]isothiazol-2(3H)-yl)propanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With hydroxylamine hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2014.01.045

Reference yield:

: 22952-24-5
6-nitrosaccharin

: 1569314-83-5
N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 60 - 80 °C

2.1: hydrogenchloride / water / 100 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

4.1: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

5.2: 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.01.045

Reference yield:

: 178755-49-2
3-(6-Nitro-1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-propionic acid ethyl ester

: 1569314-83-5
N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 100 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

3.1: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

4.2: 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2014.01.045