3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene

Base Information

• Chemical Name: 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene
• CAS No.: 181997-10-4
• Molecular Formula: C₁₇H₁₄FN₃O₂
• Molecular Weight: 311.315
• Mol file: 181997-10-4.mol

Synonyms:3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene

Chemical Property of 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene

There total 3 articles about 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 3-fluoro-4-(1H-imidazol-1-yl)phenylamine (190200-19-2) → 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene (181997-10-4)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at -20 - 20 ℃; for 48h;

DOI:10.1021/jm990373e

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene (181997-10-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / K₂CO₃ / dimethylsulfoxide / 18 h / 90 °C

2: H₂ / Pd/C / tetrahydrofuran / 18 h

3: 692 mg / NaHCO₃ / tetrahydrofuran / 48 h / -20 - 20 °C

With hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide; 1: Substitution / 2: Reduction / 3: Acylation;

DOI:10.1021/jm990373e

Reference yield:

3-fluoro-4-(1H-imidazol-1-yl)nitrobenzene (154164-56-4) → 3-fluoro-4-(1H-imidazol-1-yl)-1-(phenylmethoxycarbonylamino)benzene (181997-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran / 18 h

2: 692 mg / NaHCO₃ / tetrahydrofuran / 48 h / -20 - 20 °C

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; 1: Reduction / 2: Acylation;

DOI:10.1021/jm990373e

upstream raw materials:

benzyl chloroformate

3-fluoro-4-(1H-imidazol-1-yl)phenylamine

3,4-difluoronitrobenzene

3-fluoro-4-(1H-imidazol-1-yl)nitrobenzene

Downstream raw materials:

(5R)-3-(4-Imidazol-1-yl-3-fluorophenyl)-5-methanesulfonyloxymethyloxazolidin-2-one

(5R)-3-(4-Imidazol-1-yl-3-fluorophenyl)-5-azidomethyloxazolidin-2-one

(S)-5-aminomethyl-3-[3-fluoro-4-(1-imidazolyl)phenyl]oxazolidine-2-one

[3-[3-fluoro-4-(1H-imidazol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methanol