(+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

Base Information

Chemical Name:(+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate
CAS No.:1252592-19-0
Molecular Formula:C₂₀H₂₀N₆O₃S
Molecular Weight:424.483
Hs Code.:

Synonyms:(+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

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Chemical Property of (+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

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Technology Process of (+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

There total 9 articles about (+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1252592-17-8
(+/-)-4-{[(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl](4H-1,2,4-triazol-4-yl)amino}benzonitrile

: 1252592-19-0
(+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201000203

Reference yield:

: 1252592-13-4
(+/-)-[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]methyl 4-methylbenzenesulfonate

: 1252592-19-0
(+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C

3: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With palladium 10% on activated carbon; sulphamoyl chloride; hydrogen; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201000203

Reference yield:

: 1252592-15-6
(+/-)-4-({[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]methyl}(4H-1,2,4-triazol-4-yl)amino)benzonitrile

: 1252592-19-0
(+/-)-6-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}-5,6,7,8-tetrahydronaphthalen-2-yl sulfamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C

2: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With palladium 10% on activated carbon; sulphamoyl chloride; hydrogen; In tetrahydrofuran; methanol; N,N-dimethyl acetamide;
DOI:10.1002/cmdc.201000203